Publications

    Scientific Publications

    O'Connell A, Conover DL, Zhang Y, Seifert P, Logan-Young W, Lin CF, Sahler L, Ning R. Cone-beam CT for breast imaging: Radiation dose, breast coverage, and image quality. AJR Am J Roentgenol. 2010 Aug;195(2):496-509. doi: 10.2214/AJR.08.1017. PMID: 20651210.

    Abstract

    This pilot study compared cone-beam breast CT to mammography regarding radiation dose, breast coverage, and image quality. Results showed similar radiation doses and detection of masses/calcifications between the two methods. Cone-beam breast CT provided better coverage in certain areas but poorer coverage in the axilla. The study concludes that cone-beam breast CT effectively images the entire breast with comparable radiation dose to mammography.

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    Scientific Publications

    He N, Wu YP, Kong Y, Lv N, Huang ZM, Li S, Wang Y, Geng ZJ, Wu PH, Wei WD. The utility of breast cone-beam computed tomography, ultrasound, and digital mammography for detecting malignant breast tumors: A prospective study with 212 patients. Eur J Radiol. 2016 Feb;85(2):392-403. doi: 10.1016/j.ejrad.2015.11.029. Epub 2015 Nov 25. PMID: 26781145.

    Abstract

    Purpose: Breast cone-beam computed tomography (BCBCT) is a flat-panel detector (FPD)-based X-ray imaging system that provides high-quality images of the breast. The purpose of this study was to investigate the ability to detect breast abnormalities using non-contrast BCBCT and contrast-enhanced BCBCT (BCBCT and CE-BCBCT) compared to ultrasound (US) and digital mammography (MG).

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    Scientific Publications

    O'Connell AM, Kawakyu-O'Connor D. Dedicated Cone-beam Breast Computed Tomography and Diagnostic Mammography: Comparison of Radiation Dose, Patient Comfort, And Qualitative Review of Imaging Findings in BI-RADS 4 and 5 Lesions. J Clin Imaging Sci. 2012;2:7. doi: 10.4103/2156-7514.93274. Epub 2012 Feb 25. PMID: 22439131; PMCID: PMC3307212.

    Abstract

    Objective: This pilot study was undertaken to compare radiation dose, relative visibility/conspicuity of biopsy-proven lesions, and relative patient comfort in diagnostic mammography and dedicated cone-beam breast computed tomography (CBBCT) in Breast Imaging-Reporting and Data System (BI-RADS)(®) 4 or 5 lesions.

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    Scientific Publications

    Zhao B, Zhang X, Cai W, Conover D, Ning R. Cone beam breast CT with multiplanar and three dimensional visualization in differentiating breast masses compared with mammography. Eur J Radiol. 2015 Jan;84(1):48-53. doi: 10.1016/j.ejrad.2014.05.032. Epub 2014 Jul 15. PMID: 25439008.

    Abstract

    Objective: This pilot study was to evaluate cone beam breast computed tomography (CBBCT) with multiplanar and three dimensional (3D) visualization in differentiating breast masses in comparison with two-view mammograms.

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    Scientific Publications

    Wienbeck S, Fischer U, Luftner-Nagel S, Lotz J, Uhlig J. Contrast-enhanced cone-beam breast-CT (CBBCT): clinical performance compared to mammography and MRI. Eur Radiol. 2018 Sep;28(9):3731-3741. doi: 10.1007/s00330-018-5376-4. Epub 2018 Mar 28. PMID: 29594402.

    Abstract

    Objectives: To evaluate the diagnostic accuracy of contrast-enhanced (CE) cone-beam breast computed tomography (CBBCT) in dense breast tissue and compare it to non-contrast (NC) CBBCT, mammography (MG) and magnetic resonance imaging (MRI).

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    Scientific Publications

    Ma Y, Liu A, Zhang Y, Zhu Y, Wang Y, Zhao M, Liang Z, Qu Z, Yin L, Lu H, Ye Z. Comparison of background parenchymal enhancement (BPE) on contrast-enhanced cone-beam breast CT (CE-CBBCT) and breast MRI. Eur Radiol. 2022 Aug;32(8):5773-5782. doi: 10.1007/s00330-022-08699-2. Epub 2022 Mar 23. PMID: 35320411.

    Abstract

    Objectives: To compare the background parenchymal enhancement (BPE) levels on contrast-enhanced cone-beam breast CT (CE-CBBCT) and MRI, evaluate inter-reader reliability, and analyze the relationship between clinical factors and BPE level on CE-CBBCT.

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    Scientific Publications

    Yafei Wang, Mengran Zhao, Yue Ma, Aidi Liu, Yueqiang Zhu, Lu Yin, Zhiran Liang, Zhiye Qu, Hong Lu, Ying Ma, Zhaoxiang Ye, Accuracy of Preoperative Contrast-enhanced Cone Beam Breast CT in Assessment of Residual Tumor after Neoadjuvant Chemotherapy: A Comparative Study with Breast MRI, Academic Radiology, 2023

    Abstract

    Rationale and Objectives

    To compare the accuracy of preoperative contrast-enhanced cone beam breast CT (CE-CBBCT) and MRI in assessment of residual tumor after neoadjuvant chemotherapy (NAC).
     
    Scientific Publications

    Liu A, Ma Y, Yin L, Zhu Y, Lu H, Li H, Ye Z. Comparison of malignant calcification identification between breast cone-beam computed tomography and digital mammography. Acta Radiol. 2023 Mar;64(3):962-970. doi: 10.1177/02841851221112562. Epub 2022 Jul 11. PMID: 35815702.

    Abstract

    Background: Calcifications are important abnormal findings in breast imaging and help in the diagnosis of breast cancer. Purpose: To compare breast cone-beam computed tomography (CBCT) with digital mammography (DM) in terms of the ability to identify malignant calcifications.

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    Scientific Publications

    Zhu Y, O'Connell AM, Ma Y, Liu A, Li H, Zhang Y, Zhang X, Ye Z. Dedicated breast CT: state of the art-Part I. Historical evolution and technical aspects. Eur Radiol. 2022 Mar;32(3):1579-1589. doi: 10.1007/s00330-021-08179-z. Epub 2021 Aug 3. Erratum in: Eur Radiol. 2022 Jan 7;: PMID: 34342694.

    Abstract

    Dedicated breast CT is an emerging 3D isotropic imaging technology for breast, which overcomes the limitations of 2D compression mammography and limited angle tomosynthesis while providing some of the advantages of magnetic resonance imaging. This first installment in a 2-part review describes the evolution of dedicated breast CT beginning with a historical perspective and progressing to the present day. Moreover, it provides an overview of state-of-the-art technology. Particular emphasis is placed on technical limitations in scan protocol, radiation dose, breast coverage, patient comfort, and image artifact.

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    Scientific Publications

    Zhu Y, O'Connell AM, Ma Y, Liu A, Li H, Zhang Y, Zhang X, Ye Z. Dedicated breast CT: state of the art-Part II. Clinical application and future outlook. Eur Radiol. 2022 Apr;32(4):2286-2300. doi: 10.1007/s00330-021-08178-0. Epub 2021 Sep 3. Erratum in: Eur Radiol. 2022 Feb 14;: PMID: 34476564.

    Abstract

    Dedicated breast CT is being increasingly used for breast imaging. This technique provides images with no compression, removal of tissue overlap, rapid acquisition, and available simultaneous assessment of microcalcifications and contrast enhancement. In this second installment in a 2-part review, the current status of clinical applications and ongoing efforts to develop new imaging systems are discussed, with particular emphasis on how to achieve optimized practice including lesion detection and characterization, response to therapy monitoring, density assessment, intervention, and implant evaluation. The potential for future screening with breast CT is also addressed. KEY POINTS:

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    Scientific Publications

    Sun Y, He N, Ye F, Zhou C, Wu Y, Xie C, Tang J. Cone-beam breast CT-guided surface location facilitates breast-conserving surgery in breast cancer patients with extensive calcifications: A pilot study. Front Surg. 2023 Feb 9;10:1070868. doi: 10.3389/fsurg.2023.1070868. PMID: 36843987; PMCID: PMC9947353.

    Abstract

    Background: Extensive malignant-appearing calcifications have traditionally been considered a contraindication for breast-conserving surgery. The evaluation of calcifications largely depends on mammography, which is limited by tissue superimposition and is unable to reveal spatial information about extensive calcifications. Three-dimensional imaging modality is needed to reveal the architecture of extensive calcifications. In the present study, a novel cone-beam breast CT-guided surface location technique was investigated to facilitate breast-conserving surgery in breast cancer patients with extensive malignant breast calcifications.
     
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    Scientific Publications

    Ma Y, Cao Y, Liu A, Yin L, Han P, Li H, Zhang X, Ye Z. A Reliability Comparison of Cone-Beam Breast Computed Tomography and Mammography: Breast Density Assessment Referring to the Fifth Edition of the BI-RADS Atlas. Acad Radiol. 2019 Jun;26(6):752-759. doi: 10.1016/j.acra.2018.07.023. Epub 2018 Sep 14. PMID: 30220584.

    Abstract

    Rationale and objectives: To evaluate the reliability of cone-beam breast computed tomography (CBBCT) in visual assessment of breast density referring to the fifth edition of the Breast Imaging Reporting and Data System compared to digital mammography.

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    Scientific Publications

    Liu A, Yin L, Ma Y, Han P, Wu Y, Wu Y, Ye Z. Quantitative breast density measurement based on three-dimensional images: a study on cone-beam breast computed tomography. Acta Radiol. 2022 Aug;63(8):1023-1031. doi: 10.1177/02841851211027386. Epub 2021 Jul 14. PMID: 34259021.

    Abstract

    Background: Breast density is an independent predictor of breast cancer risk. Quantitative volumetric breast density (QVBD) is expected to provide more information on the prediction of breast cancer risk. Purpose: To evaluate the reliability of QVBD measurements based on cone-beam breast computed tomography (CBBCT) images.
     
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    Scientific Publications

    Haijie Li, Lu Yin, Ni He, Peng Han, Yueqiang Zhu, Yue Ma, Aidi Liu, Hong Lu, Zhipeng Gao, Peifang Liu, Yaopan Wu, Zhaoxiang Ye, Comparison of comfort between cone beam breast computed tomography and digital mammography, European Journal of Radiology, Volume 120, 2019, 108674, ISSN 0720-048X, https://doi.org/10.1016/j.ejrad.2019.108674.

    Abstract

    Purpose: To compare the comfort levels of cone beam breast computed tomography (CBBCT) and digital mammography.

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    Scientific Publications

    Uhlig J, Uhlig A, Biggemann L, Fischer U, Lotz J, Wienbeck S. Diagnostic accuracy of cone-beam breast computed tomography: a systematic review and diagnostic meta-analysis. Eur Radiol. 2019 Mar;29(3):1194-1202. doi: 10.1007/s00330-018-5711-9. Epub 2018 Sep 25. PMID: 30255249.

    Abstract

    Purpose: To review the published evidence on cone-beam breast computed tomography (CBBCT) and summarize its diagnostic accuracy for breast lesion assessment.

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    Scientific Publications

    Tseng HW, Karellas A, Vedantham S. Radiation dosimetry of a clinical prototype dedicated cone-beam breast CT system with offset detector. Med Phys. 2021 Mar;48(3):1079-1088. doi: 10.1002/mp.14688. Epub 2021 Jan 26. PMID: 33501686; PMCID: PMC9007273.

    Abstract

    Purpose: A clinical-prototype, dedicated, cone-beam breast computed tomography (CBBCT) system with offset detector is undergoing clinical evaluation at our institution. This study is to estimate the normalized glandular dose coefficients ( DgNCTDgNCT ) that provide air kerma-to-mean glandular dose conversion factors using Monte Carlo simulations.

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    Scientific Publications

    Vedantham S, Shi L, Glick SJ, Karellas A. Scaling-law for the energy dependence of anatomic power spectrum in dedicated breast CT. Med Phys. 2013 Jan;40(1):011901. doi: 10.1118/1.4769408. PMID: 23298092; PMCID: PMC3532103.

    Abstract

    Purpose: To determine the x-ray photon energy dependence of the anatomic power spectrum of the breast when imaged with dedicated breast computed tomography (CT).

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